Page 1 of 1

International consensus diagnostic criteria

Posted: Tue Sep 05, 2017 11:00 pm
by Grace
International consensus diagnostic criteriafor neuromyelitis optica spectrum disorders.


Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis
(MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior
NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted
or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis (IPND)
was convened to develop revised diagnostic criteria using systematic literature reviews and electronic
surveys to facilitate consensus. The new nomenclature defines the unifying term NMO
spectrum disorders (NMOSD), which is stratified further by serologic testing (NMOSD with or
without AQP4-IgG). The core clinical characteristics required for patients with NMOSD with
AQP4-IgG include clinical syndromes or MRI findings related to optic nerve, spinal cord, area
postrema, other brainstem, diencephalic, or cerebral presentations. More stringent clinical criteria,
with additional neuroimaging findings, are required for diagnosis of NMOSD without AQP4-
IgG or when serologic testing is unavailable. The IPND also proposed validation strategies and
achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasic NMOSD
and opticospinal MS. Neurology®2015;85:1–13

Full diagnostic critera can be found at source. ... l.pdf+html

Im new here

Posted: Sat Aug 18, 2018 1:38 am
by JamesSiz
Why is this thread making me so grumpy? I keep reading it over again and I don't know why

Im new here

Posted: Fri Aug 24, 2018 9:46 pm
by JamesSiz
I didn't realize I wasn't the only one interested in this. IM NOT ALONE!

Im new here

Posted: Fri Aug 24, 2018 9:54 pm
by JamesSiz
There are many ways to go about this. Many many wrong ways. Hahaha