Abstract
Objective This pilot study preliminarily examined the efficacy and tolerability of cetirizine as an add-on to standard therapy for neuromyelitis optica (NMO).
Methods Eligible participants met the Wingerchuk 2006 diagnostic criteria or had a single typical episode along with positive NMO immunoglobulin G. After baseline clinical and laboratory assessments, participants began treatment with cetirizine 10 mg orally daily, in addition to their usual disease-modifying therapy for NMO, and continued for 1 year. The primary end point was the annualized relapse rate (ARR) while on the same disease-modifying therapy before starting cetirizine compared with after taking cetirizine. Additional end points included disability (Expanded Disability Status Scale [EDSS]), relapse severity, tolerability, especially with respect to drowsiness measured by the Epworth Sleepiness Scale (ESS), and laboratory parameters.
Results The ARR before cetirizine was 0.4 ± 0.80 and after cetirizine was 0.1 ± 0.24 (p = 0.047). There was no statistically significant difference in the EDSS (mean 3.9 ± 2.18 before the start of the study and 3.2 ± 2.31 at the conclusion of the study, p = 0.500). The ESS remained fairly consistent throughout the study (mean 6.5 ± 5.33 at baseline and 6.9 ± 4.50 at month 12, p = 0.740). Laboratory studies were unrevealing.
Continued Source at:
http://nn.neurology.org/content/5/2/e441
pen-label, add-on trial of cetirizine for neuromyelitis optica
Jump to
- What is NMO
- Category: Diagnosis
- ↳ Forum: Signs and Symptoms
- ↳ Forum: International consensus diagnostic criteria
- ↳ Forum: Anti-Mog
- NMO in the news
- Category: Attacks
- ↳ Forum: Real Attacks
- ↳ Forum: Pseudo Flares
- ↳ Forum: Brain and Brain Stem
- ↳ Forum: Optic neuritis
- ↳ Forum: Transverse Myelitis (TM) and Longitudinally Extensive Transverse Myelitis (LETM)
- Category: Treatments
- ↳ Sub Category: Acute Attacks
- ↳ IVSM
- ↳ IVIG
- ↳ Plasmapheresis (Plex)
- ↳ Sub Category: Preventative
- ↳ Imuran (Azathioprine)
- ↳ CellCept
- ↳ Rituxan
- ↳ Soliris
- ↳ Actemra
- ↳ Sub Category: Spasms
- ↳ Tizanidine
- ↳ Baclofen
- ↳ Holistics
- ↳ Cannabis
- ↳ Tegretol
- ↳ Sub Category: Health/Diet
- ↳ Wahls Protocol
- ↳ Paleo Diet
- ↳ Oils
- ↳ Gluten free
- ↳ Vitamins
- ↳ China Study
- ↳ Clinical Research
- Category: Stories of NMO
- ↳ Forum: Share your Story
- Category: Support
- ↳ Forum: Kids with NMO (Pediatric)
- ↳ Forum: Teens with NMO
- ↳ Forum: Caregivers
- ↳ Forum: Coping with Diagnosis
- ↳ Forum: Patients
- ↳ Forum: Depression and Mental Health
- ↳ Sub Category: Insurance
- ↳ Forum: Service and Guide Dogs
- ↳ Forum: Companion and Support Dogs
- ↳ Forum: Events
- ↳ Forum: Facebook Groups and pages
- ↳ Forum: Advocacy
- ↳ Forum: Connecting one another
- Category: Pregnancy
- ↳ Forum: Getting Pregnant
- ↳ Forum: During Pregnancy
- ↳ Forum: After Pregnancy
- ↳ Effectiveness and safety of immunosuppressive therapy in neuromyelitis optica spectrum disorder during pregnancy.
- Category: Common Issues and Concerns
- ↳ Forum: Bladder Issues
- ↳ Forum: Bowel Issues
- ↳ Forum: Catheters
- ↳ Forum: Menstrual cycles
- ↳ Forum: Urinary tract infections (UTI)
- Category: Sexual intimacy
- ↳ Forum: Males with NMO
- ↳ Forum: Females with NMO
- Category: Disabilities
- ↳ Forum: Vision Loss
- ↳ Forum: Wheelchair-bound
- ↳ Forum: Paralysis
- Category: Reviews
- ↳ Forum: Doctors
- ↳ Forum: Hospitals
- ↳ Forum: Assistant Devices
- Category: NMO Chat Administration
- ↳ Forum: Forum Suggestions
- ↳ Forum: Moderator Assistance Request
- ↳ Forum: Trouble Tickets